이동현 교수
- Laboratory
- 유전체 안정성 실험실 (유전체 안정성)
- 연구실
- 자연대 1호관 322호, 323-2호
- 연락처
- 062-530-3418
- 이메일
- donghyunlee73@jnu.ac.kr
세부내용
- PEOPLE
- 이 동 현 (Lee, Dong-Hyun)
- 2013.02 ~ 현재 : 조교수, 전남대학교 자연과학대학 생물학과
- 2008 ~ 2013 : Postdoc Fellow, Harvard Medical School, Dana-Farber Cancer Institute
- 2003 ~ 2007 : Ph D., City of Hope, National Medical Center and Beckman Research Institute.
- 2001 ~ 2003 : Research Associate, City of Hope, National Medical Center and Beckman Research Institute.
- 이 동 현 (Lee, Dong-Hyun)
- 연구실원 (Fellow & Researchers, Doctoral Graduate Students, Masters-level Graduate Students, Undergraduate Students, Key Alumni)
- Masters-level Graduate Students
- 서 초 롱 : Phosphoproteomics를 이용한 단백질 인산화 조절 연구
- Masters-level Graduate Students
- 연구 분야 (RESEARCH INTERESTS)
- Phospho-Proteomics를 이용한 세포대사에 결정적인 역할을 하는 단백질들의 기능에 인산화 및 다른 Post-Translational Modifications (PTMs)에 의한 조절이 미치는 영향에 대한 연구
- DNA Damage Response (DDR)에서 단백질 인산화의 조절에 대한연구
- PTMs가 세포분열 (Mitosis)에 미치는 영향에 대한 연구
- Phospho-Proteomics를 이용한 Cancer Biomarker 개발
- 연구 논문 (SELECTED PUBLICATIONS)-최근 5년간
- Authors: Li YH, Wang X, Pan Y, Lee DH, Chowdhury D, Kimmelman AC.
Title: Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response. Journal: PLOS ONE, Volume: 7, Page: e39588, Year: 2012 - Authors: Nay SL, Lee DH, Bates SE, O'Connor TR.
Title: Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts. Journal: DNA Repair, Volume: 11, Page: 502-510, Year: 2012
- Authors: Lee DH, Goodarzi AA, Adelmant GO, Pan Y, Jeggo PA, Marto JA, Chowdhury D.
Title: Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. Journal: EMBO Journal, Volume: 31, Page: 2403-2415, Year: 2012 - Authors: Lee DH, Chowdhury D.
Title: What goes on must come off: phosphatases gate-crash the DNA damage response.
Journal: Trends in Biochemical Sciences, Volume: 36, Page: 569-577, Year: 2011 - Authors: Lee DH, Pan Y, Kanner S, Sung P, Borowiec JA, Chowdhury D.
Title: A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.
Journal: Nature Structural Molecular Biology, Volume: 17, Page: 365-372, Year: 2010 - Authors: Wang H, Zhao A, Chen L, Zhong X, Liao J, Gao M, Cai M, Lee DH, Li J, Chowdhury D, Yang YG, Pfeifer GP, Yen Y, Xu X.
Title: Human RIF1 encodes an anti-apoptotic factor required for DNA repair.
Journal: Carcinogenesis, Volume: 30, Page: 1314-1319, Year: 2009 - Authors: Hahn MA, Hahn T, Lee DH, Esworthy RS, Kim BW, Riggs AD, Chu FF, Pfeifer GP.
Title: Methylation of polycomb target genes in intestinal cancer is mediated by inflammation.
Journal: Cancer Research, Volume: 68, Page: 10280-10289, Year: 2008 - Authors: Lee DH, Pfeifer GP.
Title: Translesion synthesis of 7,8-dihydro-8-oxo-2'-deoxyguanosine by DNA polymerase eta in vivo.
Journal: Mutation Research, Volume: 641, Page: 19-26, Year: 2008
- Authors: Li YH, Wang X, Pan Y, Lee DH, Chowdhury D, Kimmelman AC.
- 강의 (COURSES)
- 2013년 1학기
- 생명과학의 이해
- 일반생물학 (생명공학과, 지구환경공학부)
- 2013년 1학기
- 저서
- Authors: Gerd P. Pfeifer, Dong-Hyun Lee, Jung-Hoon Yoon and Young-Hyun You
- Title: Mutations induced by UV and sunlight
- Book Name: From DNA Photolesions to Mutations, Skin Cancer and Cell Death
- Editors: Evelyne Sage, Regen Drouin, and Mahmoud Rouabhia
- Publisher: The Royal Society of Chemistry
- Location: RSC Publishing, Pages: 49-57, Year: 2005
- HONORS & AWARDS
- 2009.10-2011.08 : Ruth L. Kirschstein National Research Service Award (NRSA)/NIH
- 2010.3 : ‘Nature the Signaling Gateway’ 우수논문. DNA damage: PP4 calls a halt’
- http://www.signaling-gateway.org/update/updates/201002/su-1002-4.html
- 소속 학회 (Professional Affiliations)
- Gordon Conference : Mammalian DNA Repair