이동훈 교수
- Laboratory
- 병리생리학 실험실 (병리생리학)
- 연구실
- 자연대 1호관 418호
- 연락처
- 062-530-3408
- 이메일
- DHUN@jnu.ac.kr
세부내용
- 연구실원
- 학부생 연구원
- 학력
- 2019 01 – 2020 02 Invited Professor, Collegeof Pharmacy, ChungbukNational University, Cheongu, Chungbuk, South Korea
- 2016 03 – 2018 12 Postdoctoral Fellow, Divisionof cardiology, Departmentof Pediatrics, EmoryUniversity School of Medicine, Atlanta,Georgia, USA
- 2014 03 – 2016 02 Postdoctoral Fellow, Collegeof Pharmacy, ChungbukNational University, Cheongu,Chungbuk, South Korea
- 2009 03 – 2014 02 Combined M.S. and Ph. D in Bioscience and Biotechnology, Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul, Republic of Korea
- 1998 03 – 2005 02 B.S. in Life sciences, College of Life sciences and Biotechnology, Division of Life sciences, Korea University, Seoul, Republic of Korea
- 연구 분야
- Research for inflammatory disease based on molecular physiology
- Research for generation of vascular system using mouse stem cell
- 연구 논문
- 01. Lee YJ, Oh MJ, Lee DH, Lee YS, Lee J, Kim DH, Choi CH, Song MJ, Song HS, Hong JT Anti-inflammatory effect of bee venom in phthalic anhydride-induced atopic dermatitis animal model. Inflammopharmacology. 2020 Feb;28(1):253-263. doi: 10.1007/s10787-019-00646-w. Epub 2019 Nov 30.
- 02. Lee DH, Park MH, Hwang CJ, Kim Y, Hwang DY, Han SB, Hong JT. Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation. Cell Commun Signal. 2019 Aug 22;17(1):104. doi: 10.1186/s12964-019-0424-5. (IF = 5.111)
- 03. Lee DH, Kim TM, Kim JK, Park C. ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease Theranostics. 2019 Aug 9;9(19):5694-5705. doi: 10.7150/thno.35300 (IF = 8.063)
- 04. Lee DH, Jung YY, Park MH, Jo MR, Han SB, Yoon DY, Roh YS, Hong JT. Peroxiredoxin 6 confers protection against non‐alcoholic fatty liver disease through maintaining mitochondrial function Antioxidants & redox signaling, 2019 Aug 10;31(5):387-402. doi: 10.1089/ars.2018.7544. (IF = 5.83)
- 05. Lee DH*, Han JH*, Lee YS, Jung YS, Roh YS, Yun JS, Han SB, Hong JT Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesis Metabolism-clinical and experimental, 2019 Jun;95:46-56. doi: 10.1016/j.metabol.2019.03.010. (IF = 6.513)
- 06. Lee DH*, Kim KC*, Hwang CJ, Park KR, Jung YS, Kim SY, Kim JY, Song JK, Song MJ, Choi MK, Hwang DY, Han SB, Hong JT. Decreased Lung Tumor Development in SwAPP Mice through the Downregulation of CHI3L1 and STAT 3 Activity via the Upregulation of miRNA342-3p Mol Ther Nucleic Acids, 2019 Feb; 16:63-72 (IF = 5.919)
- 07. Lee S*, Lee DH*, Park BW, Kim R, Hoang AD.Woo SK, Xiong W, Lee YJ, Ban K, Park HJ. In vivo transduction of ETV2 improves cardiac function and induces vascular regeneration following myocardial infarction Exp Mol Med, 2019 Feb; 51(2):13 (IF = 4.743)
- 08. Hong JT, Son DJ, Lee CK, Yoon DY, Lee DH*, Park MH* Interleukin 32, inflammation and cancer Pharmacol Ther, 2017 Jun; 174:127-137 (IF = 9.396)
- 09.Son DJ, Jung YY, Seo YS, Park H, Lee DH, Kim S, Roh YS, Han SB, Yoon DY, Hong JT. Interleukin-32α Inhibits Endothelial Inflammation, Vascular Smooth Muscle Cell Activation, and Atherosclerosis by Upregulating Timp3 and Reck through suppressing microRNA-205 Biogenesis. Theranostics, 2017 Jun;7(8):2186-2203 (IF = 8.063)
- 10.Park JH, Lee DH, Park MS, Jung YS, Hong JT. C-C chemokine receptor type 5 deficiency exacerbates alcoholic fatty liver disease through pro-inflammatory cytokines and chemokines-induced hepatic inflammation J Gastroenterol Hepatol, 2017 Jun;32(6):1258-1264 (IF = 3.632)
- 11. Park MH, Lee HJ, Lee HL, Son DJ, Ju JH, Hyun BK, Jung SH, Song JK, Lee DH, Hwang CJ, Han SB, Kim S, Hong JT Parkin Knockout Inhibits Neuronal Development via Regulation of Proteasomal Degradation of p21. Theranostics, 2017 May;7(7):2033-2045 (IF = 8.063)
- 12. Lee DH*, Park MH, Hwang CJ, Hwang JY, Yoon HS, Yoon do Y, Hong JT CCR5 deficiency increased susceptibility to lipopolysaccharide-induced acute renal injury Arch Toxicol, 2016 May;90(5):1151-62 (IF = 5.741)
- 13. Lee DH, Son DJ, Park MH, Yoon DY, Han SB, Hong JT. Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced hepatic injury by modulation of T-cell activation Cell Death Dis, 2016 April;7:e2208 (IF = 5.959)
- 14. Kim DH*, Lee DH*, Jo MR, Son DJ, Park MH, Hwang CJ, Park JH, Yuk DY, Yoon DY, Jung YS, Kim Y, Jeong JH, Han SB, Hong JT. Exacerbation of collagen antibody-induced arthritis in transgenic mice overexpressing peroxiredoxin 6. Arthritis Rheumatol, 2015 Nov;67(11):3058-69 (IF = 9.002)
- 15. Lee DH*, Kim DH*, Hwang CJ, Song S, Han SB, Kim Y, Yoo HS, Jung YS, Kim SH, Yoon do Y, Hong JT. Interleukin-32γ attenuates ethanol-induced liver injury by the inhibition of cytochrome P450 2E1 e-x-p-r-e-s-s-i-o-n and inflammatory responses. Clin Sci, 2015 May, 1;128(10):695-706. (IF = 5.237)
- 16. Lee DH*, Hong JE*, Yun HM, Hwang CJ, Park JH, Han SB, Yoon do Y, Song MJ, Hong JT. Interleukin-32β ameliorates metabolic disorder and liver damage in mice fed high-fat diet. Obesity (Silver Spring). 2015 Mar;23(3):615-22. (IF = 3.969)
- 17. Hwang CJ, Yun HM, Jung YY, Lee DH, Yoon NY, Seo HO, Han JY, Oh KW, Choi DY, Han SB, Yoon do Y, Hong JT Reducing Effect of IL-32α in the Development of Stroke Through Blocking of NF-κB, but Enhancement of STAT3 Pathways. Mol Neurobiol, 2015 Apr;51(2):648-60. (IF = 4.586)
- 18. Lee YS, Kim MS, Lee DH, Kwon TH, Song HH, Oh SR, Yoon DY Luteolin 8-C-β-fucopyranoside downregulates IL-6 e-x-p-r-e-s-s-i-o-n by inhibiting MAPKs and the NF-κB signaling pathway in human monocytic cells Pharmacol Rep. 2015 Jun;67(3):581-587. (IF = 2.761)
- 19. Hyun S, Kim MS, Song YS, Bak Y, Ham SY, Lee DH, Hong J, Yoon do Y. Peroxisome Proliferator-Activated Receptor-Gamma Agonist 4-O-Methylhonokiol Induces Apoptosis by Triggering the Intrinsic Apoptosis Pathway and Inhibiting the PI3K/Akt Survival Pathway in SiHa Human Cervical Cancer Cells. J Microbiol Biotechnol. 2015 Mar 28;25(3):334-42 (IF = 1.975)
- 20. Song YS, Kim MS, Lee DH, Oh DK, Yoon DY. 15-Hydroxyeicosatetraenoic acid inhibits phorbol-12-myristate-13-Acetate-induced MUC5AC e-x-p-r-e-s-s-i-o-n in NCI-H292 respiratory epithelial cells. J Microbiol Biotechnol. 2015 May;25(5):589-97. (IF = 1.975)
- 21. Kang JW, Park YS, Kim MS, Lee DH, Bak Y, Ham SY, Song YS, Hong JT, Yoon DY. IL-32α down-regulates β2 integrin (CD18) e-x-p-r-e-s-s-i-o-n by suppressing PU.1 e-x-p-r-e-s-s-i-o-n in myeloid cells. Cell Signal. 2014 Jul;26(7):1514-22. (IF = 3.388)
- 22. Ham S, Kim KH, Kwon TH, Bak Y, Lee DH, Song YS, Park SH, Park YS, Kim MS, Kang JW, Hong JT, Yoon DY Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells. Oncol Rep. 2014 Jun;31(6):2683-91. (IF = 3.041)
- 23. Kang JW, Park YS, Lee DH, Kim MS, Bak Y, Ham SY, Park SH, Kim H, Ahn JH, Hong JT, Yoon DY Interaction network mapping among IL-32 isoforms. Biochimie. 2014 Jun;101:248-51. (IF = 3.362)
- 24. Yun HM, Park KR, Lee HP, Lee DH, Jo M, Shin DH, Yoon DY, Han SB, Hong JT. PRDX6 promotes lung tumor progression via its GPx and iPLA2 activities. Free Radic Biol Med. 2014 Apr;69:367-76. (IF = 5.657)
- 25. Jo M, Yun HM, Park KR, Park MH, Lee DH, Cho SH, Yoo HS, Lee YM, Jeong HS, Kim Y, Jung JK, Hwang BY, Lee MK, Kim ND, Han SB, Hong JT. Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6. PLoS One. 2014 Mar 11;9(3):e91508 (IF = 2.776)
- 26. Park SH, Ham S, Kwon TH, Kim MS, Lee DH, Kang JW, Oh SR, Yoon DY. Luteolin induces cell cycle arrest and apoptosis through extrinsic and intrinsic signaling pathways in MCF-7 breast cancer cells. J Environ Pathol Toxicol Oncol. 2014;33(3):219-31. (IF = 1.15)
- 27. Park YS, Kang JW, Lee DH, Kim MS, Bak Y, Yang Y, Lee HG, Hong J, Yoon DY. Interleukin-32α modulates promyelocytic leukemia zinc finger gene activity by inhibiting protein kinase Cɛ-dependent sumoylation. Int J Biochem Cell Biol. 2014 Oct;55:136-43. (IF = 3.144)
- 28. Kim MS, Kang JW, Lee DH, Bak Y, Park YS, Song YS, Ham SY, Oh DK, Hong J, Yoon DY. IL-32θ negatively regulates IL-1β production through its interaction with PKCδ and the inhibition of PU.1 phosphorylation. FEBS Lett. 2014 Aug 25;588(17):2822-9. (IF = 2.675)
- 29. Kang JW, Park YS, Lee DH, Kim MS, Bak Y, Park SH, Ham SY, Yang Y, Hong JT, Yoon DY. Interleukin-32δ interacts with IL-32β and inhibits IL-32β-mediated IL-10 production. FEBS Lett. 2013 Nov 29;587(23):3776-81. (IF = 2.675)
- 30. Kim MS, Bak Y, Park YS, Lee DH, Kim JH, Kang JW, Song HH, Oh SR, Yoon DY. Wogonin induces apoptosis by suppressing E6 and E7 e-x-p-r-e-s-s-i-o-ns and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. Cell Biol Toxicol. 2013 Aug;29(4):259-72. (IF = 5.097)
- 31. Lee DH, Kang JW, Song YS, Kim JH, Kim MS, Bak YS, Oh DK, Yoon DY. Compound K attenuates lipid accumulation through down-regulation of peroxisome proliferator-activated receptor γ in 3T3-L1 cells J Korean Soc Appl Bi. 2013 Apr;56(2):141-47. (IF = 1.559)
- 32. Park SH, Kim JH, Lee DH, Kang JW, Song HH, Oh SR, Yoon DY. Luteolin 8-C-β-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-κB signaling in MCF-7 breast cancer cells. Biochimie. 2013 Nov;95(11):2082-90. (IF = 3.362)
- 33. Kang JW, Park YS, Kim MS, Lee DH, Bak Y, Ham SY, Park SH, Hong JT, Yoon DY Interleukin (IL)-32β-mediated CCAAT/enhancer-binding protein α (C/EBPα) phosphorylation by protein kinase Cδ (PKCδ) abrogates the inhibitory effect of C/EBPα on IL-10 production. J Biol Chem. 2013 Aug 16;288(33):23650-8. (IF = 4.106)
- 34. Yun HM, Oh JH, Shim JH, Ban JO, Park KR, Kim JH, Lee DH, Kang JW, Park YH, Yu D, Kim Y, Han SB, Yoon DY, Hong JT Antitumor activity of IL-32β through the activation of lymphocytes, and the inactivation of NF-κB and STAT3 signals CELL DEATH DIS. 2013 May 23;4:e640. doi: 10.1038/cddis.2013.166.. (IF = 5.959)
- 35. Kim MS, Kim JH, Bak Y, Park YS, Lee DH, Kang JW, Shim JH, Jeong HS, Hong JT, Yoon DY. 2,4-bis (p-hydroxyphenyl)-2-butenal (HPB242) induces apoptosis via modulating E7 e-x-p-r-e-s-s-i-o-n and inhibition of PI3K/Akt pathway in SiHa human cervical cancer cells. Nutr Cancer. 2012;64(8):1236-44. (IF = 2.029)
- 36. Kim EJ*, Lee DH*, Kim HJ, Lee SJ, Ban JO, Cho MC, Jeong HS, Yang Y, Hong JT, Yoon DY Thiacremonone, a sulfur compound isolated from garlic, attenuates lipid accumulation partially mediated via AMPK activation in 3T3-L1 adipocytes. J Nutr Biochem. 2012 Dec;23(12):1552-8. (IF = 4.490)
- 37. Ban JO*, Lee DH*, Kim EJ, Kang JW, Kim MS, Cho MC, Jeong HS, Kim JW, Yang Y, Hong JT, Yoon do Y Antiobesity effects of a sulfur compound thiacremonone mediated via down-regulation of serum triglyceride and glucose levels and lipid accumulation in the liver of db/db mice. Phytother Res. 2012 Sep;26(9):1265-71. (IF = 3.766)
- 38. Kang JW, Park YS, Lee DH, Kim JH, Kim MS, Bak Y, Hong J, Yoon DY. Intracellular interaction of interleukin (IL)-32α with protein kinase Cε (PKCε ) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells. J Biol Chem. 2012 Oct 12;287(42):35556-64. (IF = 4.106)
- 39. Bak Y, Kim H, Kang JW, Lee DH, Kim MS, Park YS, Kim JH, Jung KY, Lim Y, Hong J, Yoon DY. A synthetic naringenin derivative, 5-hydroxy-7,4'-diacetyloxyflavanone-N-phenyl hydrazone (N101-43), induces apoptosis through up-regulation of Fas/FasL e-x-p-r-e-s-s-i-o-n and inhibition of PI3K/Akt signaling pathways in non-small-cell lung cancer cells.. J Agric Food Chem. 2011 Sep 28;59(18):10286-97. (IF = 3.571)
- 40. Cho MC*, Lee DH*, Kim EJ, Lee JY, Kang JW, Song JH, Chong Y, Kim Y, Hong JT, Yoon DY Novel PPARγ partial agonists with weak activity and no cytotoxicity; identified by a simple PPARγ ligand screening system. Mol Cell Biochem. 2011 Dec;358(1-2):75-83. (IF = 2.884)
- 41. Kim JH, Kang JW, Kim M, Lee DH, Kim H, Choi HS, Kim EJ, Chung IM, Chung IY, Yoon DY. The liquid Panax ginseng inhibits epidermal growth factor-induced metalloproteinase 9 and cyclooxygenase 2 e-x-p-r-e-s-s-i-o-ns via inhibition of inhibitor factor kappa-B-alpha and extracellular signal-regulated kinase in NCI-H292 human airway epithelial cells. Am J Rhinol Allergy. 2011 Mar-Apr;25(2):e55-9. (IF = 2.015)
- 42. Lee S, Kim H, Kang JW, Kim JH, Lee DH, Kim MS, Yang Y, Woo ER, Kim YM, Hong J, Yoon DY. The biflavonoid amentoflavone induces apoptosis via suppressing E7 e-x-p-r-e-s-s-i-o-n, cell cycle arrest at sub-G₁ phase, and mitochondria-emanated intrinsic pathways in human cervical cancer cells. J Med Food. 2011 Jul-Aug;14(7-8):808-16. (IF = 2.020)
- 43. Kim EJ, Kim H, Lee S, Kang JW, Lee DH, Choi HS, Kim JM, Yang Y, Sheen YY, Park SN, Yoon do Y. Melphalan modulates the e-x-p-r-e-s-s-i-o-n of E7-specific biomarkers in E7-Tg mice. Anticancer Res. 2010 Jul;30(7):2773-83. (IF = 1.94)